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Invitrogen
Phospho-ErbB2 (HER-2) (Tyr1248) Recombinant Rabbit Monoclonal Antibody (HL1466)
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图: 1 / 8
Phospho-ErbB2 (HER-2) (Tyr1248) Antibody (MA5-46898) in ICC/IF
Immunofluorescence analysis of ERBB2 was performed using 70% confluent log phase A-431 cells that were serum starved for 16 hours and then treated with EGF (100 ng/mL, 5 minutes). The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Phospho-ErbB2 (HER-2) (Tyr1248... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-46898
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
HL1466
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human HER2 (phospho Tyr1248). The exact sequence is proprietary.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Store as concentrated solution.
Centrifuge briefly prior to opening vial.
靶标信息
ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; metas; Metastatic lymph node gene 19 protein; MLN 19; NEU proto-oncogene; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
基因别名: ERBB2; HER2; MLN19; NEU; NGL
Entrez Gene ID: (Rat) 24337
RNA polymerase I core binding
glycoprotein binding
DNA binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
transmembrane signaling receptor activity
protein binding
ATP binding
protein C-terminus binding
growth factor binding
protein phosphatase binding
ubiquitin protein ligase binding
identical protein binding
protein heterodimerization activity
Hsp90 protein binding
transmembrane signal receptor
liver development
positive regulation of protein phosphorylation
transcription, DNA-templated
signal transduction
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
central nervous system development
peripheral nervous system development
heart development
skeletal muscle tissue development
neuromuscular junction development
motor neuron axon guidance
positive regulation of cell proliferation
glial cell differentiation
phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
positive regulation of cell growth
response to progesterone
regulation of microtubule-based process
negative regulation of immature T cell proliferation in thymus
wound healing
regulation of cell proliferation
response to drug
myelination
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
tongue development
estrous cycle
regulation of cell differentiation
positive regulation of translation
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase I promoter
positive regulation of transcription from RNA polymerase III promoter
positive regulation of Ras protein signal transduction
protein autophosphorylation
sympathetic nervous system development
response to axon injury
oligodendrocyte differentiation
positive regulation of epithelial cell proliferation
mammary gland involution
regulation of ERK1 and ERK2 cascade
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