Invitrogen

Phospho-FOXO1/FOXO3 (Ser322, Ser325) Polyclonal Antibody

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说明书
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Phospho-FOXO1/FOXO3 (Ser322, Ser325) Polyclonal Antibody

产品信息

PA5-40217

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化 (IHC)

1:100-1:300
-

酶联免疫吸附实验 (ELISA)

1:5,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human FoxO1/3 around the phosphorylation site of S322/S325.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2576790

产品详细信息

This antibody is predicted to react with human and rat based on sequence homology.

靶标信息

a transcription factor of the forkhead family. A central regulator of metabolism in several cell types. May play an important role in myogenic growth and differentiation, and in the regulation of lipolysis in adipocytes by controlling the expression of adipose triglyceride lipase (ATGL), the rate-limiting lipolytic enzyme. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. Contains 1 fork-head domain.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AF6q21 protein; AFX; AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3A; Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO4; MGC120490; MLLT7

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基因别名: 1110048B16Rik; 2010203A17Rik; AF6q21; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; FKHRL1; FKHRL1P2; FOXO1; FOXO1A; FOXO2; FOXO3; FOXO3A

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UniProt ID: (Human) Q12778, (Human) O43524, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH4

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Entrez Gene ID: (Human) 2308, (Human) 2309, (Rat) 84482, (Mouse) 56458, (Mouse) 56484, (Rat) 294515

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功能
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding chromatin binding protein binding beta-catenin binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding core promoter binding transcription cofactor binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein kinase binding chromatin DNA binding transcription factor binding
参与通路
negative regulation of transcription from RNA polymerase II promoter ovulation from ovarian follicle initiation of primordial ovarian follicle growth antral ovarian follicle growth oocyte maturation transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter regulation of translation apoptotic process anatomical structure morphogenesis cell differentiation DNA damage response, signal transduction by p53 class mediator cellular response to oxidative stress glucose homeostasis positive regulation of neuron apoptotic process positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance extrinsic apoptotic signaling pathway in absence of ligand regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process blood vessel development autophagy cellular response to DNA damage stimulus insulin receptor signaling pathway cellular response to starvation positive regulation of autophagy cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of cell proliferation positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process cellular response to hyperoxia cellular response to nitric oxide regulation of nucleic acid-templated transcription tumor necrosis factor-mediated signaling pathway temperature homeostasis cellular glucose homeostasis protein acetylation endocrine pancreas development fat cell differentiation negative regulation of transcription, DNA-templated enamel mineralization cellular response to hydrogen peroxide cellular response to cold cellular response to dexamethasone stimulus response to fluoride regulation of energy homeostasis
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