Bioss

Phospho-FOXO4/FOXO1 (Ser197, Ser256) Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Phospho-FOXO4/FOXO1 (Ser197, Ser256) Polyclonal Antibody

产品信息

BS-3144R

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic phosphopeptide derived from human FOXO4 around the phosphorylation site of Ser197.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

内含物

0.02% ProClin 300

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

These genes encode a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. Multiple transcript variants encoding different isoforms have been found for these genes. Both function as transcription factors involved in the regulation of the insulin signaling pathway.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Afxh; Fork head domain transcription factor AFX1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); Forkhead box protein O1; Forkhead box protein O1A; Forkhead box protein O4; Forkhead in rhabdomyosarcoma; forkhead protein; forkhead protein 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7

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基因别名: AFX; AFX1; Afxh; AI876417; FKH1; FKHR; Fkhr1; Fkhr3; FOXO1; FOXO1A; FOXO4; MLLT7; RGD1561201

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UniProt ID: (Human) Q12778, (Human) P98177, (Rat) G3V7R4, (Mouse) Q9R1E0, (Mouse) Q9WVH3

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Entrez Gene ID: (Human) 2308, (Human) 4303, (Rat) 84482, (Mouse) 56458, (Rat) 302415, (Mouse) 54601

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功能
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, transcription factor binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription coactivator binding chromatin binding protein binding beta-catenin binding ubiquitin protein ligase binding sequence-specific DNA binding protein phosphatase 2A binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor binding enzyme binding identical protein binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
参与通路
regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cell cycle arrest mitotic G2 DNA damage checkpoint negative regulation of cell proliferation insulin receptor signaling pathway negative regulation of angiogenesis positive regulation of transcription, DNA-templated stem cell differentiation negative regulation of smooth muscle cell differentiation negative regulation of G0 to G1 transition negative regulation of transcription from RNA polymerase II promoter blood vessel development autophagy apoptotic process cellular response to DNA damage stimulus cellular response to starvation positive regulation of autophagy cellular response to insulin stimulus negative regulation of stress-activated MAPK cascade cellular response to oxidative stress regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of cell proliferation glucose homeostasis positive regulation of apoptotic process negative regulation of apoptotic process negative regulation of fat cell differentiation positive regulation of gluconeogenesis positive regulation of protein catabolic process positive regulation of transcription from RNA polymerase II promoter cellular response to hyperoxia cellular response to nitric oxide negative regulation of canonical Wnt signaling pathway neuronal stem cell population maintenance regulation of nucleic acid-templated transcription regulation of neural precursor cell proliferation regulation of reactive oxygen species metabolic process transcription, DNA-templated anatomical structure morphogenesis cell differentiation temperature homeostasis cellular glucose homeostasis protein acetylation endocrine pancreas development fat cell differentiation negative regulation of transcription, DNA-templated enamel mineralization cellular response to hydrogen peroxide cellular response to cold cellular response to dexamethasone stimulus response to fluoride regulation of energy homeostasis cell cycle multicellular organism development muscle organ development positive regulation of cell cycle arrest
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