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Invitrogen
Phospho-GluR1 (Ser831) Polyclonal Antibody
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产品信息
PA1-84839
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to amino acid sequence within GluR1 which includes phosphorylated Ser831
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.01% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Predicted to react with chicken, dog, human and mouse based on sequence homology.
For the detection of phosphoproteins, serine phosphatase inhibitors such as 10mM NaF should be added to the sample buffer. Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background. PA1-84839 detects a band of ~100kDa in rat brain lysates.
Rabbit anti Rat GluR1 (pSer831) antibody recognizes glutamate receptor 1 (GluR1), also known as AMPA-selective glutamate receptor 1, GluR-A, GluR-K1 and glutamate receptor ionotropic , AMPA 1 (GluA1), when phosphorylated at serine 831.
靶标信息
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AI853806; AMPA-selective glutamate receptor 1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluR1; GluRK1; glutamate receptor; Glutamate receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; NR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1
基因别名: GluA1; gluR-A; Glur1; Gria1
UniProt ID: (Rat) P19490
Entrez Gene ID: (Rat) 50592
G-protein alpha-subunit binding
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
protein binding
adenylate cyclase binding
protein kinase binding
protein domain specific binding
PDZ domain binding
small GTPase binding
myosin V binding
G-protein beta-subunit binding
beta-2 adrenergic receptor binding
identical protein binding
protein homodimerization activity
protein kinase A binding
transmembrane signal receptor
regulation of receptor recycling
chemical synaptic transmission
long-term memory
response to toxic substance
response to lithium ion
response to organic cyclic compound
neuronal action potential
spinal cord development
receptor internalization
response to estradiol
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
synaptic transmission, glutamatergic
response to cocaine
response to drug
response to peptide hormone
positive regulation of membrane potential
response to arsenic-containing substance
regulation of synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
response to electrical stimulus
long term synaptic depression
response to fungicide
cellular response to amino acid stimulus
cellular response to dsRNA
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to organic cyclic compound
cellular response to amine stimulus
