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Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant Rabbit Monoclonal Antibody (8H4J9)

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Phospho-HDAC4/HDAC5/HDAC9 (Ser246, Ser259, Ser220) Recombinant Rabbit Monoclonal Antibody (8H4J9)

产品信息

MA5-51562

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化（石蜡） (IHC (P))

1:100-1:400
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

8H4J9

抗原

Synthetic peptide
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.84 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3094411

靶标信息

Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the eta-amino groups of lysines located near the amino termini of core histone proteins (1). Eight members of HDAC family have been identified in the past several years (2,3). These HDAC family members are divided into two classes, I and II. Class I of the HDAC family comprises four members, HDAC-1, 2, 3, and 8, each of which contains a deacetylase domain exhibiting from 45 to 93% identity in amino acid sequence. Class II of the HDAC family comprises HDAC-4, 5, 6, and 7, the molecular weights of which are all about twofold larger than those of the class I members, and the deacetylase domains are present within the C-terminal regions, except that HDAC-6 contains two copies of the domain, one within each of the N-terminal and C-terminal regions. Human HDAC-1, 2 and 3 were expressed in various tissues, but the others (HDAC-4, 5, 6, and 7) showed tissue-specific expression patterns (3). These results suggested that each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Antigen NY-CO-9; DKFZp779K1053; HD4; HD5; HD7; HD7b; HD9; hdac-9; Histone deacetylase 4; histone deacetylase 4/5-related protein; Histone deacetylase 5; Histone deacetylase 7B; Histone deacetylase 9; histone deacetylase A; histone deacetylase mHDA1; Histone deacetylase-related protein; MEF-2 interacting transcription repressor (MITR) protein; MEF2-interacting transcription repressor MITR

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基因别名: 4932408F19Rik; AHO3; AI047285; AI426555; AV022454; BDMR; D030072B18Rik; HA6116; HD4; HD5; HD7; HD7B; HD9; HDAC; HDAC-4; HDAC-A; HDAC4; HDAC5; HDAC7; HDAC7B; HDAC9; HDAC9B; HDAC9FL; HDACA; HDRP; KIAA0288; KIAA0600; KIAA0744; mHDA1; MITR; mKIAA0600; mKIAA0744; NY-CO-9; RGD1310748; RGD1563092

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UniProt ID: (Human) P56524, (Human) Q9UQL6, (Human) Q9UKV0, (Rat) Q99P99, (Mouse) Q6NZM9, (Mouse) Q99N13

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Entrez Gene ID: (Human) 9759, (Human) 10014, (Human) 9734, (Rat) 363287, (Mouse) 208727, (Rat) 84580, (Mouse) 15184, (Rat) 687001, (Mouse) 79221

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功能
RNA polymerase III transcription factor binding core promoter binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding zinc ion binding protein kinase binding potassium ion binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity activating transcription factor binding histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding protein kinase C binding metal ion binding molecular_function DNA binding NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) hydrolase activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding histone modifying enzyme
参与通路
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast development chromatin remodeling transcription, DNA-templated inflammatory response nervous system development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of lamellipodium assembly negative regulation of myotube differentiation regulation of cardiac muscle contraction by calcium ion signaling response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress positive regulation of smooth muscle cell migration chromatin modification histone deacetylation B cell differentiation positive regulation of protein sumoylation peptidyl-lysine deacetylation regulation of gene expression, epigenetic B cell activation response to drug regulation of protein binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of osteoblast differentiation negative regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of sequence-specific DNA binding transcription factor activity response to interleukin-1 histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus positive regulation of reactive oxygen species biosynthetic process chromatin organization chromatin silencing protein deacetylation regulation of myotube differentiation response to activity neuron differentiation cellular response to insulin stimulus response to cocaine cellular response to lipopolysaccharide negative regulation of cell migration involved in sprouting angiogenesis regulation of histone H3-K9 acetylation response to amphetamine heart development regulation of striated muscle cell differentiation positive regulation of cell migration involved in sprouting angiogenesis histone H3-K9 modification regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organismal response to stress renal tubule morphogenesis cellular response to fluid shear stress positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation negative regulation of gene expression negative regulation of striated muscle tissue development biological_process
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