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Phospho-IGF1R beta (Tyr1161) Polyclonal Antibody

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Phospho-IGF1R beta (Tyr1161) Polyclonal Antibody

产品信息

PA5-37601

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

-
查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:100
-

免疫细胞化学 (ICC/IF)

1:100-1:200
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of tyrosine 1161(D-I-Y(p)-E-T)derived from Human IGF-1R.
3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2554209

产品详细信息

A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human breast carcinoma; suggested positive control for ICC/IF is MCF-7 cells.

靶标信息

IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and beta-subunits, which are disulfide-linked in a beta-alpha-alpha-beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: IGF-I receptor; insulin-like growth factor I receptor; insulin-like growth factor-I receptor precursor; line 186; protein-tyrosine kinase (EC 2.7.1.112); type-I IGF receptor; unnamed protein product

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基因别名: A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; IGF-1R; IGFIR; IGFIRC; IGFR; Igfr1; JTK13

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UniProt ID: (Human) P08069, (Mouse) Q60751, (Rat) P24062

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Entrez Gene ID: (Human) 3480, (Mouse) 16001, (Rat) 25718

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功能
protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity insulin-activated receptor activity insulin-like growth factor-activated receptor activity insulin receptor binding structural molecule activity protein binding insulin-like growth factor binding ATP binding insulin-like growth factor I binding identical protein binding phosphatidylinositol 3-kinase binding insulin binding insulin receptor substrate binding G-protein alpha-subunit binding macromolecular complex binding protein transporter activity
参与通路
protein phosphorylation immune response transmembrane receptor protein tyrosine kinase signaling pathway axonogenesis brain development positive regulation of cell proliferation insulin receptor signaling pathway epidermis development organ morphogenesis negative regulation of muscle cell apoptotic process cerebellum development establishment of cell polarity male sex determination adrenal gland development positive regulation of cell migration mammary gland development exocrine pancreas development neuron projection development positive regulation of cytokinesis cellular response to insulin stimulus positive regulation of osteoblast proliferation peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of protein complex disassembly negative regulation of MAPK cascade positive regulation of MAPK cascade estrous cycle transcytosis response to ethanol positive regulation of mitotic nuclear division negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of JNK cascade protein autophosphorylation insulin-like growth factor receptor signaling pathway positive regulation of developmental growth positive regulation of smooth muscle cell proliferation positive regulation of axon regeneration positive regulation of DNA metabolic process positive regulation of meiotic cell cycle positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling prostate gland epithelium morphogenesis cellular response to glucose stimulus cellular response to transforming growth factor beta stimulus positive regulation of steroid hormone biosynthetic process positive regulation of cell cycle process dendritic spine maintenance beta-amyloid clearance postsynaptic modulation of chemical synaptic transmission positive regulation of cold-induced thermogenesis response to L-glutamate negative regulation of hepatocyte apoptotic process negative regulation of cholangiocyte apoptotic process cellular response to beta-amyloid cellular response to insulin-like growth factor stimulus signal transduction protein kinase B signaling cellular response to oxygen-containing compound cardiac atrium development response to hormone hippocampus development response to nutrient levels response to insulin response to vitamin E cellular response to zinc ion starvation response to nicotine response to alkaloid cellular response to mechanical stimulus cellular response to estradiol stimulus cellular response to progesterone stimulus cellular response to testosterone stimulus cellular response to dexamethasone stimulus cellular senescence cellular response to aldosterone cellular response to angiotensin
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