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Invitrogen
Phospho-JAK1 (Tyr1022, Tyr1023) Polyclonal Antibody
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产品信息
PA1-28444
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho peptide (Human). The sequence is conserved in mouse and pig.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-28444 detects JAK1 from human samples.
PA1-28444 has been successfully used in Western blot applications.
The PA1-28444 immunogen is: Synthetic phospho peptide (Human). The sequence is conserved in mouse and pig.
靶标信息
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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