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Invitrogen
Phospho-LAT (Tyr132) Polyclonal Antibody
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Phospho-LAT (Tyr132) Antibody (PA1-26640) in WB
Western blot detection of Phospho-LAT pTyr132 in extracts prepared from Jurkat E6.1 cells were left unstimulated (lane 1) or stimulated (lanes 2-5). Samples were resolved by SDS-PAGE on a 10% polyacrylamide gel and transferred to PVDF. Membranes were blocked with a 5% BSA-TBST buffer overnight at 4°C and probed using a Phospho-LAT pTyr132 polyclonal antibody (Product # PA1-26640).
产品信息
PA1-26640
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to a portion of human LAT containing tyrosine 132.
偶联物
形式
Liquid
浓度
0.35 mg/mL
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-26640 detects LAT (phospho Y132) from human samples. PA1-26640 is expected to cross react with mouse (85% conserved), rat (77% conserved) due to sequence homology.
PA1-26640 has been successfully used in Western blot procedures.
The PA1-26640 immunogen is a synthetic phosphopeptide corresponding to a portion of human LAT containing tyrosine 132.
靶标信息
LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FcepsilonRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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