Invitrogen

Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody

Name: Phospho-MER\/SKY (Tyr749, Tyr681) Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-40270

1 篇参考文献

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (1)

Phospho-MER/SKY (Tyr749, Tyr681) Antibody in Western Blot (WB)

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Phospho-MER/SKY (Tyr749, Tyr681) Antibody (PA5-40270) in WB

Western Blot analysis of Phospho-MER/SKY (Tyr749, Tyr681) was performed using 3T3 cells. The membrane was probed with Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody (Product # PA5-40270).

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Immunogen image

Immunogen Image Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody

产品信息

PA5-40270

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:2,000

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免疫组化 (IHC)

1:100-1:300

酶联免疫吸附实验 (ELISA)

1:10,000

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2608093

产品详细信息

This antibody is predicted to react with mouse and rat based on sequence homology.

靶标信息

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: Bruton agammaglobulinemia tyrosine kinase; c-mer proto-oncogene tyrosine kinase; EC 2.7.10.2; Etk2/tyro3; kinase Syk; KSYK; MER receptor tyrosine kinase; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; retinal dystrophy; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; TK19-2; Tyro 12; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF

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基因别名: AI323366; Brt; BYK; c-Eyk; c-mer; DTK; Etk-2; etk2/tyro3; Eyk; MER; MERTK; nmf12; Nyk; rdy; Rek; RP38; RSE; SKY; TIF; TK19-2; Tyro12; TYRO3