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Invitrogen
Phospho-MUNC18 (Ser515) Polyclonal Antibody
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产品信息
PA1-4689
产品规格
种属反应
Rat
已发表种属
Mouse,
Rhesus monkey
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser515 of rat STXBP2 conjugated to KLH
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and Xenopus based on 100% sequence homology.
In Western blot, this antibody is specific for the ~65 kDa Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide used as the antigen but not by the corresponding dephosphopeptide.
靶标信息
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: EIEE4; FLJ37475; hUNC18; MGC146482; munc-18c; N-Sec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; rbSec1; rop; RP11-56D16.3; Syntaxin-binding protein 1; unc-18 homolog; unc-18-1; Unc-18A; Unc18-1
基因别名: ANC18HA; Munc18-1; n-sec1; nSec1; NSEC1A; rbSec1; rbSec1A; rbSec1B; Sec1; Stxbp1; Unc18-1; Unc18a
UniProt ID: (Rat) P61765
Entrez Gene ID: (Rat) 25558
platelet degranulation
exocytosis
vesicle docking involved in exocytosis
neurotransmitter secretion
neuromuscular synaptic transmission
axon target recognition
regulation of synaptic vesicle priming
protein transport
synaptic vesicle maturation
negative regulation of synaptic transmission, GABAergic
negative regulation of neuron apoptotic process
positive regulation of exocytosis
positive regulation of calcium ion-dependent exocytosis
protein stabilization
long term synaptic depression
platelet aggregation
protein localization to plasma membrane
