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PA1-26734 detects PKC beta 1 + PKC beta 2 (phospho T500) from human samples. PA1-26734 is expected to cross react with mouse and rat due to sequence homology.
PA1-26734 has been successfully used in Western blot procedures.
The PA1-26734 immunogen is a synthetic phosphopeptide corresponding to a portion of human PKC beta 1 & 2 containing threonine 500.
Store at 4°C short term. For longer storage, store at -20°C, Avoiding freeze/thaw cycles.
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。