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Invitrogen
Phospho-PRKAR2B (Ser114) Polyclonal Antibody
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产品信息
PA1-26735
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to a portion of human PKA regulatory 2 beta subunit containing serine 114.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-26735 detects PKA 2 beta (regulatory subunit) (phospho S114) from human and mouse samples. PA1-26735 is expected to cross react with bovine (100% conserved), rabbit (100% conserved), and rat (100% conserved) due to sequence homology.
PA1-26735 has been successfully used in Western blot procedures.
The PA1-26735 immunogen is a synthetic phosphopeptide corresponding to a portion of human PKA regulatory 2 beta subunit containing serine 114.
靶标信息
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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