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Invitrogen
Phospho-RARA/RARB (Ser96) Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-64622
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human Retinoic Acid Receptor alpha/beta (Phospho-Ser96)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Phospho-RARA/RARB (Ser96) Polyclonal Antibody detects endogenous levels of RARA/RARB only when phosphorylated at Ser96.
靶标信息
Retinoic acid, a metabolite of vitamin A, is necessary for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. Retinoic acid functions through its interaction with the nuclear protein, retinoic acid receptor (RAR). RAR belongs to the steroid and thyroid hormone superfamily of nuclear receptor proteins which exert their effects by binding to specific DNA response elements, thus regulating gene expression in target cells. RAR exists as three major subtypes: alpha, beta and gamma.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HBV-activated protein; Nuclear receptor subfamily 1 group B member 1; Nuclear receptor subfamily 1 group B member 2; RAR alpha 1; RAR-alpha; RAR-beta; RAR-epsilon; retinoic acid; retinoic acid receptor; Retinoic acid receptor alpha; Retinoic acid receptor beta
基因别名: A830025K23; HAP; NR1B1; NR1B2; RAR; RARA; RARalpha1; RARB
UniProt ID: (Mouse) P11416, (Mouse) P22605
Entrez Gene ID: (Rat) 24705, (Mouse) 19401, (Rat) 24706, (Mouse) 218772
translation repressor activity, nucleic acid binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region DNA binding
retinoic acid binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
retinoic acid receptor activity
transcription coactivator activity
transcription corepressor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
receptor binding
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein domain specific binding
chromatin DNA binding
phosphatidylinositol 3-kinase regulator activity
histone deacetylase binding
protein kinase B binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoic acid-responsive element binding
protein heterodimerization activity
mRNA 5'-UTR binding
protein kinase A binding
alpha-actinin binding
regulatory region DNA binding
metal ion binding
protein complex binding
retinoid X receptor binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
ureteric bud development
neural tube closure
liver development
glandular epithelial cell development
outflow tract septum morphogenesis
growth plate cartilage development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
protein phosphorylation
signal transduction
germ cell development
spermatogenesis
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
male gonad development
positive regulation of gene expression
negative regulation of gene expression
positive regulation of phosphatidylinositol 3-kinase signaling
negative regulation of translation
hippocampus development
intracellular estrogen receptor signaling pathway
prostate gland development
regulation of granulocyte differentiation
negative regulation of granulocyte differentiation
embryonic camera-type eye development
regulation of myelination
response to estradiol
response to retinoic acid
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of interleukin-13 production
positive regulation of interleukin-4 production
positive regulation of interleukin-5 production
response to vitamin A
response to cytokine
multicellular organism growth
regulation of apoptotic process
negative regulation of apoptotic process
apoptotic cell clearance
steroid hormone mediated signaling pathway
regulation of phosphatidylinositol 3-kinase activity
response to ethanol
negative regulation of cell differentiation
positive regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of translational initiation
regulation of synaptic plasticity
retinoic acid receptor signaling pathway
positive regulation of binding
positive regulation of protein kinase B signaling
ventricular cardiac muscle cell differentiation
Sertoli cell fate commitment
limb development
face development
bone development
trachea cartilage development
chondroblast differentiation
negative regulation of cartilage development
positive regulation of ERK1 and ERK2 cascade
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to estrogen stimulus
retinal pigment epithelium development
striatum development
neurogenesis
negative regulation of chondrocyte differentiation
embryonic hindlimb morphogenesis
positive regulation of apoptotic process
positive regulation of programmed cell death
embryonic eye morphogenesis
embryonic digestive tract development
retina development in camera-type eye
regulation of transcription from RNA polymerase II promoter
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