Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Phospho-RSK1/RSK2 (Ser221, Ser227) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
PA5-149486
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Phosphopeptide containing human RSK1 S221 site
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
RSK1 (Ribosomal S6 Kinase 1) and RSK2 (Ribosomal S6 Kinase 2) are genes that encode members of the RSK family of serine/threonine kinases, which are downstream effectors of the extracellular signal-regulated kinase (ERK) signaling pathway. These kinases play critical roles in regulating various cellular processes, including growth, proliferation, survival, and differentiation. RSK1 and RSK2 are activated by phosphorylation in response to extracellular signals such as growth factors, hormones, and mitogens. Once activated, they phosphorylate a range of substrates, including transcription factors, ribosomal proteins, and other kinases, thereby influencing gene expression and protein synthesis. Dysregulation of RSK1 and RSK2 activity has been implicated in several pathological conditions, including cancer, where they can promote tumor growth and survival, and neurodevelopmental disorders, such as Coffin-Lowry syndrome, which is associated with mutations in the RSK2 gene. Understanding the function and regulation of RSK1 and RSK2 is essential for developing targeted therapies aimed at modulating their activity in disease contexts. Research into these kinases provides valuable insights into the broader mechanisms of ERK signaling and its impact on cellular physiology and disease progression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
