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Invitrogen
Phospho-Rb (Thr356) Polyclonal Antibody
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产品信息
OPA1-03200
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide based on the threonine 356 region of human Rb.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
50 µg
保存条件
-80°C, Avoid Freeze/Thaw Cycles
运输条件
Dry ice
RRID
产品详细信息
OPA1-03200 detects phosphorylated Rb (retinoblastoma protein) (Thr356) from human samples.
OPA1-03200 has been successfully used in Western blot procedures. By Western blot, this antibody detects a ~110 kDa protein representing phospho-Rb from Jurkat cell lysate.
The OPA1-03200 immunizing peptide is based on the threonine 356 region of human Rb. This sequence is 80% and 87% conserved in mice and rat, respectively.
靶标信息
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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