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Invitrogen
Phospho-STAT5 alpha/beta (Ser726, Ser731) Polyclonal Antibody
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Phospho-STAT5 alpha/beta (Ser726, Ser731) Antibody (PA5-35655) in WB
Western blot analysis of Phospho-STAT5 alpha pSer726+beta pSer731 in EGF-treated Jurkat whole cell lysates with a blocking peptide (lane 1) and no blocking peptide (lane 2) using a Phospho-STAT5 alpha pSer726+beta pSer731 polyclonal antibody (Product # PA5-35655).
产品信息
PA5-35655
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human STAT5A/B around the phosphorylation site of Serine 726/731
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
This antibody reacts with human Phospho-STAT5 alpha pSer726 + beta pSer731, and with mouse and rat Phospho-STAT5 alpha pSer725 + beta pSer730.
靶标信息
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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