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7TM Antibodies
Phospho-Somatostatin Receptor 3 (Ser337, Thr341) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-Somatostatin Receptor 3 (Ser337, Thr341) Antibody (7TM0357A) in WB
Agonist-induced Serine337/Threonine341 phosphorylation of the Somatostatin Receptor 3. Upper panel, HEK293 cells stably expressing the Somatostatin Receptor 3 (SST3) were either not exposed or exposed to 1 µM SRIF (somatotropin-release inhibiting factor) or 1 µM of artificial somatostatin receptor Agonist Octreotide for 30 minutes. Cells were lysed and immunoblotted with the anti-pS337/pT341-SST3 antibody (... View More
Product Details
7TM0357A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphopeptide derived from human SST3 around the phosphorylation site of Ser337/Thr341.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
Dulbecco's PBS, pH 7.4
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: somatostatin receptor; Somatostatin receptor type 3; SS-3-R; SSR-28
Gene Aliases: SS-3-R; SS3-R; SS3R; SSR-28; SSTR3
UniProt ID: (Human) P32745
Entrez Gene ID: (Human) 6753
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
cell-cell signaling
chemical synaptic transmission
spermatogenesis
negative regulation of cell proliferation
hormone-mediated apoptotic signaling pathway
cerebellum development
forebrain development
somatostatin signaling pathway
response to starvation
cellular response to glucocorticoid stimulus
cellular response to estradiol stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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