Invitrogen

Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)

Name: Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)
Brand: Invitrogen
SKU: MA5-45027

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (5)

Phospho-Tau-F (Thr231) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-Tau-F (Thr231) Antibody (MA5-45027) in IHC (P)

Immunohistochemistry analysis of Phospho-Tau(T231) in paraffin-embedded mouse brain tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 1% BSA for 20 minutes at room temperature, washed with ddH2O and PBS, and then probed with Phospho-Tau(T231) Monoclonal antibody (Product # MA5-45027) using a dilution of 1:200 ... View More

Phospho-Tau-F (Thr231) Antibody in Immunohistochemistry (Frozen) (IHC (F))

Phospho-Tau-F (Thr231) Antibody in Western Blot (WB)

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Immunogen image

Immunogen Image Phospho-Tau-F (Thr231) Recombinant Rabbit Monoclonal Antibody (SC58-08)

产品信息

MA5-45027

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:800

免疫组化（冰冻） (IHC (F))

1:50-1:800

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

SC58-08

抗原

Synthetic phospho-peptide corresponding to residues surrounding Thr231 of human Tau-F.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

TBS, pH 7.4, with 0.05% BSA, 40% glycerol

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_2931481

靶标信息

Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity. Tau is highly subject to a variety of post-translational modifications, including phosphorylation on serine and threonine residues, polyubiquitination (and subsequent proteasomal degradation) and glycation of specific Tau isoforms. Defects in the gene encoding Tau are associated with Alzheimers disease, pallido-ponto-nigral degeneration (PPND), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: 2N4R; G protein beta1/gamma2 subunit-interacting factor 1; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; protein phosphatase 1, regulatory subunit 103; Tau microtubule-associated protein; Tau-4

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基因别名: AI413597; AW045860; DDPAC; FTDP-17; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PPND; PPP1R103; pTau; RNPTAU; TAU

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UniProt ID: (Human) P10636, (Mouse) P10637

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Entrez Gene ID: (Human) 4137, (Rat) 29477, (Mouse) 17762

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