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Invitrogen
Phospho-ZAP70/Syk (Tyr493, Tyr526) Recombinant Rabbit Monoclonal Antibody (Zap70Y493-H11), APC
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Phospho-ZAP70/Syk (Tyr493, Tyr526) Antibody (MA5-36918) in Flow
Flow cytometry of Phospho-Zap70 (Tyr493, Tyr526) using Jurkat cells. Samples were incubated in monoclonal Phospho-Zap70 (Tyr493, Tyr526) antibody (Product # MA5-36918). Images correspond with the following conditions: negative control (blue), stained and untreated (red), treated with pervanadate (green).
产品信息
MA5-36918
产品规格
宿主/亚型
Rabbit
/ IgG, kappa
分类
Recombinant Monoclonal
类型
Antibody
克隆号
Zap70Y493-H11
抗原
A synthetic phospho-peptide corresponding to residues surrounding Tyr493 of human phospho Zap70.
偶联物
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
保存条件
2-8°C
运输条件
Wet ice
靶标信息
ZAP-70 is a cytosolic protein tyrosine kinase that is a member of the Syk family of proteins. ZAP-70 is expressed exclusively in T-cells and natural killer cells and is required for T-cell receptor activation. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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