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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
This antibody is predicted to react with Monkey, Pig and Mouse.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit Superclonal™ antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production. Note: Formerly called “Recombinant polyclonal antibody”, this product is now rebranded as “Recombinant Superclonal™ antibody”. The physical product and the performance remain unchanged.
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns c-Abl into an oncogene. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for c-Abl. In chronic myelogenous leukemia and a subset of acute lymphoblastic leukemias, the c-Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome). As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-ABL potentially regulates DNA repair by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Abelson murine leukemia oncogene; Abelson murine leukemia viral (v-abl) oncogene homolog 1; abelson murine leukemia viral oncogene homolog 1; Abelson tyrosine-protein kinase 1; Abl 1 antib; ABL kinase domain; abl protein; ABL protooncogene 1 nonreceptor tyrosine kinase; ABL1; ABL2; ABLL; ARG; B30; BCR-ABL1 p190; BCR/ABL e8a2 fusion; BCR/ABL variant p190 fusion protein; BCR/ABL variant-p210 fusion protein; BCR/ABL1 e1a2 fusion protein; BCR/ABL1 fusion; BCR/ABL1 fusion protein e3a1; bcr/c-abl oncogene protein; BCR::ABL1 fusion protein; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; c-abl protein, type I; c-abl protein, type II; c-abl protein, type III; c-abl-protein type I; c-abl-protein type II; c-abl-protein type III; c-abl-protein type IV; chimeric BCR::ABL1 protein; H1681-BCR/ABL variant p210 fusion protein; non-receptor tyrosine kinase; p150; p190; proto-oncogene c-Abl; proto-oncogene tyrosine-protein kinase ABL1; RP11-83J21.1; Tyrosine kinase ARG; tyrosine kinase protein; tyrosine-protein kinase ABL1-like; unnamed protein product; v-abl Abelson murine leukemia oncogene 1; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1
基因别名: ABL; BCR-ABL; bcr/abl; c-ABL; c-ABL1; CHDSKM; E430008G22Rik; JTK7; p150; v-abl
UniProt ID: (Human) P00519, (Mouse) P00520
Entrez Gene ID: (Human) 25, (Rat) 311860, (Mouse) 11350