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Invitrogen
Phospho-c-Raf (Ser338, Tyr340) Polyclonal Antibody
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产品信息
PA1-26656
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to a portion of human c-Raf containing serine 338 and tyrosine 340. The sequence is conserved in mouse and rat.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
50 µg
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-26656 detects c-Raf (phospho S338 + Y340) from human samples. PA1-26656 is expected to cross react with mouse (100% conserved) and rat (100% conserved) due to sequence homology.
PA1-26656 has been successfully used in Western blot procedures. The predicted molecular weight is 74 kDa. Suggested positive controls for this product are Immunoprecipitates or cell lysates from Hek293 cells transfected with c-Raf, or co-transfected with c-Raf, Ras[V12] and Rac 1.
The PA1-26656 immunogen is a synthetic phosphopeptide corresponding to a portion of human c-Raf containing serine 338 and tyrosine 340. The sequence is conserved in mouse and rat.
靶标信息
Raf-1 (c-Raf) is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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