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Invitrogen
Phospho-gamma Catenin (Tyr550) Polyclonal Antibody
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Phospho-gamma Catenin (Tyr550) Antibody (PA5-143668) in ICC/IF
Immunocytochemistry analysis of Phospho-gamma Catenin (Tyr550) in control (Top) and pervanadate-treated (Bottom) A431 cells. The cells were co-labeled with mouse monoclonal gamma-Catenin antibody or rabbit Phospho-gamma Catenin (Tyr550) polyclonal antibody (Product # PA5-143668), then the antibodies were detected using appropriate secondary antibodies conjugated to Cy2 or Cy3.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-143668
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Phospho-gamma-Catenin (Tyr-550) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 550 of human gamma-Catenin. This peptide sequence is highly conserved in rat and mouse gamma-Catenin.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA, 50% glycerol
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody was cross-adsorbed to both phospho-tyrosine coupled to agarose and to dephosphorylated gamma-Catenin (Tyr-550) peptide before affinity purification using phospho-gamma-Catenin (Tyr-550) peptide (without carrier). The antibody detects an 84kDa* protein corresponding to the molecular mass of gamma-Catenin on SDS-PAGE immunoblots of A431 and Hct116 src transformed cells treated with pervanadate (1 mM for 30 min), but not in control cells.
靶标信息
JUP is a major cytoplasmic protein which is the only known constituent common to sub membranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: catenin (cadherin-associated protein), gamma 80kDa; desmoplakin III; desmoplakin-3; desmosomal protein 3; gamma-catenin; gamma-catenin (plakoglobin); OTTHUMP00000164735; unnamed protein product
基因别名: CTNNG; D930025P04Rik; DP3; DPIII; PDGB; PG; PKGB
UniProt ID: (Human) P14923, (Mouse) Q02257, (Rat) Q6P0K8
Entrez Gene ID: (Human) 3728, (Mouse) 16480, (Rat) 81679
transcription coactivator activity
structural molecule activity
protein binding
ligand-dependent nuclear receptor binding
protein phosphatase binding
alpha-catenin binding
cadherin binding
cell adhesion molecule binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
microtubule cortical anchor activity
protein kinase binding
macromolecular complex binding
protein tyrosine kinase binding
positive regulation of cell-matrix adhesion
desmosome assembly
cell adhesion
cell migration
regulation of cell proliferation
positive regulation of protein import into nucleus
negative regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
positive regulation of axon extension
positive regulation of transcription from RNA polymerase II promoter
detection of mechanical stimulus
canonical Wnt signaling pathway
endothelial cell-cell adhesion
cellular response to indole-3-methanol
protein localization to plasma membrane
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
positive regulation of canonical Wnt signaling pathway
cell-cell adhesion
regulation of ventricular cardiac muscle cell action potential
positive regulation of cellular protein localization
skin development
cell-cell junction organization
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