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Invitrogen
Phospho-mTOR (Ser2448) Recombinant Mouse Monoclonal Antibody (MRRBY)
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Phospho-mTOR (Ser2448) Antibody (740274M) in WB
Western blot was performed using Phospho-mTOR (Ser2448) Recombinant Mouse Monoclonal Antibody (MRRBY) (Product # 740274M) and a ~288 kDa band corresponding to Phospho-mTOR (Ser2448) was observed upon treatment in A-431 cells. Whole cell extracts (60 µg lysate) of A-431 (Lane 1) and A-431 serum starved overnight and treated with Human EGF Recombinant Protein (Product #PHG0311) , 100 ng/mL for 15 minutes were... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
740274M
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
MRRBY
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This is an engineered recombinant antibody that was developed to provide superior sensitivity without changing the paratope. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro.
The advantages of recombinant antibodies include better specificity, lot-to-lot consistency and improved signal-to-noise ratio.
It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
靶标信息
FRAP1 (mTOR) is a serine/threonine kinase that plays a critical role in cellular growth and proliferation. Perturbations in the mTOR/PI3-kinase/AKT pathway are associated with numerous forms of cancer. FRAP1 is also the target of rapamycin and its analogues, which are currently used as immunosuppressants and cancer therapeutics. Mutations affecting the gene results in Smith-Kingsmore syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; m-TOR; Mammalian target of rapamycin; Mechanistic target of rapamycin; mTOR; mTORC1; Rapamycin and FKBP12 target 1; Rapamycin target protein 1; Serine/threonine-protein kinase mTOR; Tyrosine-protein kinase mTOR
基因别名: FRAP; FRAP1; FRAP2; MTOR; RAFT1; RAPT1
Entrez Gene ID: (Human) 2475
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