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Nordic
Phosphodiesterase II Polyclonal Antibody, Biotin
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产品信息
NE125-BIO
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Bovine Phosphodiesterase II
偶联物
形式
Lyophilized
浓度
10 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstituted by adding 1.0 mL sterile distilled water, spun down to remove insoluble particles, divided into small aliquots, frozen and stored at or below -20°C.
Cross-reactivities against enzymes of other sources may occur but have not been determined.
Prior to use, an aliquot is thawed slowly at ambient temperature, spun down again and used to prepare working dilutions by adding sterile phosphate buffered saline (PBS, pH 7.2). Repeated thawing and freezing should be avoided. Working dilutions should be stored at 4°C, not refrozen, and preferably used the same day. If a slight precipitation occurs upon storage, this should be removed by centrifugation. It will not affect the performance of the product.
靶标信息
PDE2A (phosphodiesterase 2A) is a 100 kD cyclic nucleotide phosphodiesterase (PDE) and three isoforms of PDE2A have been reported (PDE2A1, PDE2A2 and PDE2A3) which arise from a single gene by alternative splicing events. PDE2A can degrade both cAMP and cGMP, but degrades cGMP with greater efficacy. PDE2A is expressed in a variety of tissue types, with greatest expression in the brain, where it is localized in the cerebellum and neocortex. PDE2A has been implicated in penile erectile dysfunction and in the regulation of fluid and inflammatory cell transport across the endothelial cell barrier.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: c-GMP stimulated phosphodiesterase; cGMP-dependent 3',5'-cyclic phosphodiesterase; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated
基因别名: CGS-PDE; cGSPDE; PDE2A
UniProt ID: (Bovine) P14099
Entrez Gene ID: (Bovine) 281971
negative regulation of transcription from RNA polymerase II promoter
signal transduction
cAMP-mediated signaling
cGMP-mediated signaling
cellular response to drug
cellular response to macrophage colony-stimulating factor stimulus
negative regulation of vascular permeability
positive regulation of vascular permeability
negative regulation of cAMP-mediated signaling
GMP catabolic process
cGMP catabolic process
positive regulation of inflammatory response
establishment of endothelial barrier
cellular response to mechanical stimulus
cellular response to cGMP
cellular response to granulocyte macrophage colony-stimulating factor stimulus
