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Plakoglobin Monoclonal Antibody (PG 5.1)

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Plakoglobin Monoclonal Antibody (PG 5.1)

产品信息

61005PROGEN

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:25-1:100
-

免疫组化（冰冻） (IHC (F))

1:25-1:100
-

免疫细胞化学 (ICC/IF)

1:5
-
产品规格

种属反应

Bovine, Human, Mouse, Rat, Zebrafish

宿主/亚型

Mouse / IgG2b

分类

Monoclonal

类型

Antibody

克隆号

PG 5.1

抗原

Plakoglobin,
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 0.5% BSA

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute lyophilized product with 1 mL distilled water.

PG 5.1 represents an excellent marker for all forms of intercellular adhering junctions, such as: desmosomes of epithelial and myocardial cells (incl. cultured cells); zonulae and fasciae adherentes of epithelia, endothelia of blood vessels and myocardial cells; adherens-type junctions (e.g. lens tissue, pigmented retinal cells, Sertoli cells of testis). The PG 5.1 epitope maps within the C-terminus at the extreme end of repeat 13 (aa 632-687) of plakoglobin. Polypeptide reacting: MW 83 000 Plakoglobin, "band 5" polypeptide of intercellular adhering junctions (identical to gamma-catenin)Reactivity on cultured cell lines: Cell cultures forming monolayers .

靶标信息

JUP is a major cytoplasmic protein which is the only known constituent common to sub membranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: catenin (cadherin-associated protein), gamma 80kDa; Catenin gamma; Desmoplakin III; Desmoplakin-3; gama-catenin; Gamma-catenin; gamma-catenin (plakoglobin); Junction plakoglobin; Junction plakoglobin a; OTTHUMP00000164735; Plakoglobin; Plakoglobin-1a

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基因别名: ARVD12; cb80; CTNNG; D930025P04Rik; danPG; DP3; DPIII; fb11b06; JUP; jupa; PDGB; PG; PKGB; wu:fb11b06

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UniProt ID: (Bovine) Q8SPJ1, (Human) P14923, (Rat) Q6P0K8, (Mouse) Q02257, (Zebrafish) Q9PVF7

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Entrez Gene ID: (Bovine) 445543, (Human) 3728, (Rat) 81679, (Mouse) 16480, (Zebrafish) 30415

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功能
structural molecule activity protein binding protein homodimerization activity transcription coactivator activity signal transducer activity structural constituent of cell wall protein kinase binding protein phosphatase binding alpha-catenin binding cadherin binding cell adhesion molecule binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cadherin binding involved in cell-cell adhesion nuclear hormone receptor binding
参与通路
positive regulation of cell-matrix adhesion desmosome assembly cell migration regulation of cell proliferation positive regulation of protein import into nucleus negative regulation of blood vessel endothelial cell migration skin development positive regulation of angiogenesis detection of mechanical stimulus positive regulation of sequence-specific DNA binding transcription factor activity endothelial cell-cell adhesion cellular response to indole-3-methanol protein localization to plasma membrane bundle of His cell-Purkinje myocyte adhesion involved in cell communication regulation of heart rate by cardiac conduction regulation of ventricular cardiac muscle cell action potential atrioventricular valve morphogenesis negative regulation of Wnt signaling pathway involved in heart development cell adhesion heart development negative regulation of Wnt signaling pathway positive regulation of transcription from RNA polymerase II promoter cytoskeletal anchoring at plasma membrane signal transduction single organismal cell-cell adhesion adherens junction organization adherens junction assembly protein heterooligomerization establishment of protein localization to plasma membrane positive regulation of canonical Wnt signaling pathway regulation of cell fate specification ventricular cardiac muscle cell action potential bundle of His cell to Purkinje myocyte communication regulation of nucleic acid-templated transcription
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