Bioss

Polycystin 2 Polyclonal Antibody

问题与答案

问题与答案

问题与答案

Additional Information:

{{banner.description}}

{{$ctrl.isSkuNotesCollapsed ? 'View more' : 'View less'}}

抗体检测数据 (1)

Polycystin 2 Antibody in Western Blot (WB)

Polycystin 2 Antibody in Western Blot (WB)

图: 1 / 1

Polycystin 2 Antibody (BS-24450R) in WB

Lane 1:Human Panc-1 cell lysates; Lane 2: Human A549 cell lysates; Lane 3: Human Huvec cell lysates; Lane 4: Human Siha cell lysates probed with Polycystin 2 Polyclonal Antibody, Unconjugated (bs-24450R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.

Polycystin 2 Antibody in Western Blot (WB)

Product Image Gallery

Polycystin 2 Antibody in Western Blot (WB) — Lane 1:Human Panc-1 cell lysates; Lane 2: Human A549 cell lysates; Lane 3: Human Huvec cell lysates; Lane 4: Human Siha cell lysates probed with Polycystin 2 Polyclonal Antibody, Unconjugated (bs-24450R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.

产品信息

BS-24450R

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:5,000

-

酶联免疫吸附实验 (ELISA)

1:500-1:1,000

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide derived from human Polycystin 2

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

100 µg

纯化类型

Protein A

保存液

TBS, pH 7.4, with 1% BSA, 50% glycerol

内含物

0.03% ProClin 300

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Polycystin-2 (PC2), encoded by the PKD2 gene, is a multi-pass membrane protein that functions as a nonselective calcium-permeable cation channel, primarily localized to the primary cilium and endoplasmic reticulum. It plays a key role in calcium signaling and mechanosensation, often forming a complex with polycystin-1 to regulate cellular responses to fluid flow. Mutations in PKD2 disrupt these processes and lead to autosomal dominant polycystic kidney disease (ADPKD).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: autosomal dominant polycystic kidney disease type II; Autosomal dominant polycystic kidney disease type II protein; PC2; PKD2; polycystic kidney disease 2 (autosomal dominant); Polycystic kidney disease 2 protein; Polycystin-2; Polycystwin; R48321; Transient receptor potential cation channel subfamily P member 2; unnamed protein product

查看更多收起

基因别名: APKD2; Pc-2; PC2; PKD2; PKD4; TRPP1; TRPP2

查看更多收起

UniProt ID: (Human) Q13563

查看更多收起

Entrez Gene ID: (Human) 5311

查看更多收起

receptor binding voltage-gated ion channel activity voltage-gated calcium channel activity voltage-gated sodium channel activity voltage-gated potassium channel activity cation channel activity calcium channel activity potassium channel activity sodium channel activity calcium ion binding protein binding cytoskeletal protein binding channel activity outward rectifier potassium channel activity voltage-gated cation channel activity identical protein binding protein homodimerization activity actinin binding HLH domain binding ion channel binding metal ion binding calcium-induced calcium release activity ATPase binding phosphoprotein binding muscle alpha-actinin binding transcription regulator inhibitor activity

branching involved in ureteric bud morphogenesis kidney development liver development embryonic placenta development heart looping detection of nodal flow ion transport potassium ion transport sodium ion transport calcium ion transport cellular calcium ion homeostasis cell surface receptor signaling pathway JAK-STAT cascade determination of left/right symmetry heart development negative regulation of cell proliferation positive regulation of gene expression Wnt signaling pathway calcium-mediated signaling spinal cord development neural tube development ion transmembrane transport cellular response to reactive oxygen species metanephric part of ureteric bud development sodium ion transmembrane transport aorta development regulation of cell proliferation chordate embryonic development cilium organization positive regulation of nitric oxide biosynthetic process positive regulation of transcription from RNA polymerase II promoter embryonic organ development detection of mechanical stimulus release of sequestered calcium ion into cytosol protein tetramerization protein homotetramerization protein heterotetramerization centrosome duplication establishment of localization in cell regulation of cell cycle placenta blood vessel development renal tubule morphogenesis renal artery morphogenesis calcium ion transmembrane transport cellular response to calcium ion cellular response to cAMP cellular response to hydrostatic pressure cellular response to osmotic stress cellular response to fluid shear stress potassium ion transmembrane transport determination of liver left/right asymmetry metanephric mesenchyme development mesonephric tubule development mesonephric duct development metanephric smooth muscle tissue development metanephric cortex development metanephric ascending thin limb development metanephric cortical collecting duct development metanephric distal tubule development metanephric S-shaped body morphogenesis regulation of calcium ion import inorganic cation transmembrane transport positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway negative regulation of G1/S transition of mitotic cell cycle