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Invitrogen
Protein Tyrosine Phosphatase Polyclonal Antibody
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Protein Tyrosine Phosphatase Antibody (PA5-112868) in WB
Western Blot analysis of Protein Tyrosine Phosphatase in Recombinant protein using a Protein Tyrosine Phosphatase polyclonal antibody (Product # PA5-112868) at a concentration of 3.1 µg/ml. A goat anti rabbit polyclonal secondary antibody was used at a dilution of 1:50,000.
产品信息
PA5-112868
产品规格
种属反应
Zebrafish
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Zebrafish Protein tyrosine phosphatase, receptor type, s, a protein (269-424AA)
偶联物
形式
Liquid
浓度
3.12 mg/mL
纯化类型
Protein G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
PRL-3 is a newly identified metastasis-related gene, which codes a 22 KDa non-classical protein tyrosine phosphatase with a C-terminal prenylation motif. It is located at the cytoplasmic membrane when prenylated and in the nucleus when nonpreylated. PRL-3 has at least 75% amino-acid sequence similarity with PRL-1 and PRL-2, the other two members of the PRL family. Recently, Zeng and colleagues found that Chinese hamster ovary cells stably expressing PRL-3 exhibited enhanced motility, invasive activity, and induced metastatic tumor formation in nude mice. And in clinical study, PRL-3 is consistently overexpressed in liver metastasis in colorectal cancer cells. These findings suggest PRL-3 is a new target for the early diagnosis of metastasis as well as the drug discovery.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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