Invitrogen

Prothrombin Polyclonal Antibody

查看其他26个Prothrombin抗体

问题与答案

问题与答案

问题与答案

产品信息

PA1-43039

应用

建议稀释比

已发表文章

免疫印迹 (WB)

10 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Sheep / IgG

分类

Polyclonal

类型

Antibody

抗原

Human Prothrombin.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

8.2 mg/mL

纯化类型

SDS-PAGE

保存液

50% water with 50% glycerol

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

PA1-43039 detects Prothrombin in human samples.

PA1-43039 has successfully been used in Western blot and ELISA applications.

PA1-43039 was derived from human prothrombin.

靶标信息

Prothrombin or Coagulation factor II, is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothrombin; prothrombin B-chain; serine protease

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基因别名: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1

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UniProt ID: (Mouse) P19221, (Human) P00734

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Entrez Gene ID: (Mouse) 14061, (Human) 2147

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serine-type endopeptidase activity receptor binding calcium ion binding protein binding growth factor activity thrombospondin receptor activity protease serine protease protein modifying enzyme

positive regulation of protein phosphorylation signal peptide processing proteolysis ER to Golgi vesicle-mediated transport acute-phase response cell surface receptor signaling pathway multicellular organism development blood coagulation blood coagulation, intrinsic pathway positive regulation of cell proliferation regulation of cell shape response to wounding regulation of gene expression negative regulation of platelet activation positive regulation of phosphatidylinositol 3-kinase signaling response to inactivity peptidyl-glutamic acid carboxylation platelet activation regulation of blood coagulation positive regulation of blood coagulation positive regulation of cell growth positive regulation of collagen biosynthetic process fibrinolysis cellular protein metabolic process negative regulation of proteolysis negative regulation of astrocyte differentiation leukocyte migration positive regulation of release of sequestered calcium ion into cytosol regulation of cytosolic calcium ion concentration negative regulation of fibrinolysis cellular response to mechanical stimulus positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of reactive oxygen species metabolic process