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Invitrogen
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Immunogen sequence: YLFKLLLIGD SGVGKSCLLL RFADDTYTES YISTIGVDFK IRTIELDGKT IKLQIWDTAG QERFRTITSS YYRGAHGIIV VYDVTDQESY ANVKQWLQEI DRYASENVNK LLVGNKSDLT TKKVVDNTTA KEFADSLGIP FLETSAKNAT NVEQAFMTMA AEIKKRMGPG AASGGERPNL KIDSTPVKPA GGGCC; Positive Samples: NCI-H460, SKOV3, 293T, MCF7, Mouse kidney, Mouse heart, Mouse brain; Cellular Location: Cytoplasm, Cytoplasmic side, Lipid-anchor, Membrane, Preautophagosomal structure membrane
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: RAB1B-like, member RAS oncogene family; Ras-related protein Rab-1B; small GTP-binding protein
基因别名: 1110011F09Rik; RAB1B; Rab1bl
UniProt ID: (Human) Q9H0U4, (Mouse) Q9D1G1
Entrez Gene ID: (Human) 81876, (Rat) 100126191, (Mouse) 76308