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Invitrogen
RAB5 Polyclonal Antibody
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产品信息
PA3-915
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant human Rab5.
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存液
whole serum
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA3-915 detects Rab5 from human and rat samples.
PA3-915 has been successfully used in Western blot and immunofluorescence procedures.
The PA3-915 immunogen is recombinant human Rab5.
靶标信息
RAB5 are among the small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Rab 5; Rab 5A; Ras related protein; RAS-associated protein RAB5A; Ras-related protein Rab-5A; Small GTP-binding protein rab5
基因别名: RAB5; RAB5A
UniProt ID: (Human) P20339, (Rat) M0RC99
Entrez Gene ID: (Human) 5868, (Rat) 64633
endocytosis
phagocytosis
small GTPase mediated signal transduction
blood coagulation
protein transport
regulation of endocytosis
synaptic vesicle recycling
early endosome to late endosome transport
positive regulation of exocytosis
regulation of endosome size
regulation of filopodium assembly
receptor internalization involved in canonical Wnt signaling pathway
regulation of synaptic vesicle exocytosis
regulation of autophagosome assembly
endosome organization
positive regulation of smooth muscle cell migration
vesicle-mediated transport
regulation of long-term neuronal synaptic plasticity
positive regulation of smooth muscle cell proliferation
