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Invitrogen
RAMP3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-117067
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein (or fragment).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.67 mg/mL
规格
167 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: MCF7, SW620, Mouse brain, Mouse skin, Mouse kidney, Mouse heart, Mouse eye, Rat brain, Rat lung
Immunogen sequence: METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEV
靶标信息
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: calcitonin receptor-like receptor activity modifying protein 3; Calcitonin-receptor-like receptor activity-modifying protein 3; CRLR activity-modifying protein 3; membrane protein; RAMP3; RAMP3; receptor (calcitonin) activity modifying protein 3; receptor (G protein-coupled) activity modifying protein 3; Receptor activity-modifying protein 3; type I transmembrane protein; unnamed protein product
基因别名: RAMP3
Entrez Gene ID: (Human) 10268, (Mouse) 56089, (Rat) 56820
positive regulation of receptor recycling
calcium ion transport
intracellular protein transport
G-protein coupled receptor signaling pathway
adenylate cyclase-activating G-protein coupled receptor signaling pathway
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of gene expression
protein transport
receptor internalization
cellular response to hormone stimulus
cross-receptor inhibition within G protein-coupled receptor heterodimer
positive regulation of calcium-mediated signaling
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
cellular response to estradiol stimulus
protein localization to plasma membrane
G-protein coupled receptor signaling pathway involved in heart process
amylin receptor signaling pathway
positive regulation of cAMP/PKA signal transduction
amylin receptor 3 signaling pathway
positive regulation of protein localization to plasma membrane
response to amyloid-beta
adrenomedullin receptor signaling pathway
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