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Invitrogen
RASGRP1 Polyclonal Antibody
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产品信息
PA5-65431
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Human RASGRP1
偶联物
形式
Liquid
浓度
0.3 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: RKTAQDTLYVL PSPTSPCPSP VLVRKRAFVK WENKDSLIKS KEELRHLRLP TYQELEQEIN TLKADNDALK IQLKYAQKKI ESLQLEKSNH VLAQMEQGD
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 82%.
靶标信息
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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