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RBPJ Monoclonal Antibody (2F12G12)

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RBPJ Monoclonal Antibody (2F12G12)

产品信息

66132-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-
产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

2F12G12

抗原

RBPJ Fusion Protein Ag6302 (138-486 aa encoded by BC064976)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.45 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: DIGVFLSKR IKVISKPSKK KQSLKNADLC IASGTKVALF NRLRSQTVST RYLHVEGGNF HASSQQWGAF FIHLLDDDES EGEEFTVRDG YIHYGQTVKL VCSVTGMALP RLIIRKVDKQ TALLDADDPV SQLHKCAFYL KDTERMYLCL SQERIIQFQA TPCPKEPNKE MINDGASWTI ISTDKAEYTF YEGMGPVLAP VTPVPVVESL QLNGGGDVAM LELTGQNFTP NLRVWFGDVE AETMYRCGES MLCVVPDISA FREGWRWVRQ PVQVPVTLVR NDGIIYSTSL TFTYTPEPGP RPHCSAAGAI LRANSSQVPP NESNTNSEGS YTNASTNSTS VTSSTATVVS (138-486 aa encoded by BC064976)

靶标信息

CSL plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. The protein is abundantly expressed in heart and skeletal muscle and expression is increased by passive stretch. Mutations in this gene can lead to X-linked deafness.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CBF-1; H-2K binding factor-2; immunoglobulin kappa J region recombination signal binding protein 1; J kappa-recombination signal-binding protein; RBP-J; RBP-J kappa; RBP-JK; rbp-jkappa; Recombining binding protein suppressor of hairless; Renal carcinoma antigen NY-REN-30; suppressor of hairless homolog

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基因别名: AOS3; CBF1; csl; IGKJRB; IGKJRB1; KBF2; RBP-J; RBPJ; RBPJK; RBPSUH; SUH

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UniProt ID: (Human) Q06330

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Entrez Gene ID: (Human) 3516

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功能
recombinase activity RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II repressing transcription factor binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding sequence-specific DNA binding protein N-terminus binding DNA-binding transcription factor
参与通路
negative regulation of transcription from RNA polymerase II promoter angiogenesis somitogenesis epithelial to mesenchymal transition blood vessel remodeling inflammatory response to antigenic stimulus secondary heart field specification outflow tract morphogenesis endocardium morphogenesis epithelial to mesenchymal transition involved in endocardial cushion formation cardiac left ventricle morphogenesis ventricular trabecula myocardium morphogenesis regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation DNA recombination transcription initiation from RNA polymerase II promoter humoral immune response Notch signaling pathway positive regulation of transcription of Notch receptor target negative regulation of cell proliferation auditory receptor cell fate commitment epidermal cell fate specification pituitary gland development B cell differentiation keratinocyte differentiation negative regulation of ossification positive regulation of BMP signaling pathway somatic stem cell population maintenance dorsal aorta morphogenesis atrioventricular canal development defense response to bacterium myeloid dendritic cell differentiation negative regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of timing of cell differentiation sebaceous gland development hair follicle maturation positive regulation of cardiac muscle cell proliferation Clara cell differentiation labyrinthine layer blood vessel development arterial endothelial cell fate commitment Notch signaling involved in heart development positive regulation of transcription from RNA polymerase II promoter in response to hypoxia blood vessel lumenization interleukin-4 secretion blood vessel endothelial cell fate specification positive regulation of ERBB signaling pathway positive regulation of ephrin receptor signaling pathway positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment positive regulation of cell proliferation involved in heart morphogenesis
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