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Proteintech
RDH12 Polyclonal Antibody
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产品信息
13289-3-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RDH12 Fusion Protein Ag3850 (1-316 aa encoded by BC025724)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MLVTLGLLT SFFSFLYMVA PSIRKFFAGG VCRTNVQLPG KVVVITGANT GIGKETAREL ASRGARVYIA CRDVLKGESA ASEIRVDTKN SQVLVRKLDL SDTKSIRAFA EGFLAEEKQL HILINNAGVM MCPYSKTADG FETHLGVNHL GHFLLTYLLL EQLKVSAPAR VVNVSSVAHH IGKIPFHDLQ SEKRYSRGFA YCHSKLANVL FTRELAKRLQ GTGVTTYAVH PGVVRSELVR HSSLLCLLWR LFSPFVKTAR EGAQTSLHCA LAEGLEPLSG KYFSDCKRTW VSPRARNNKT AERLWNVSCE LLGIRWE (1-316 aa encoded by BC025724)
靶标信息
The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: All-trans and 9-cis retinol dehydrogenase; LCA3; Retinol dehydrogenase 12; retinol dehydrogenase 12, all-trans and 9-cis; Short chain dehydrogenase/reductase family 7C member 2; short chain dehydrogenase/reductase family 7C, member 2
基因别名: A930033N07Rik; LCA13; RDH12; RP53; SDR7C2
UniProt ID: (Human) Q96NR8, (Mouse) Q8BYK4
Entrez Gene ID: (Human) 145226, (Rat) 314264, (Mouse) 77974
retinol dehydrogenase activity
protein binding
NADP-retinol dehydrogenase activity
molecular_function
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
aldo-keto reductase (NADP) activity
isocitrate dehydrogenase activity
mevaldate reductase activity
gluconate dehydrogenase activity
steroid dehydrogenase activity
oxidoreductase activity
epoxide dehydrogenase activity
5-exo-hydroxycamphor dehydrogenase activity
2-hydroxytetrahydrofuran dehydrogenase activity
acetoin dehydrogenase activity
phenylcoumaran benzylic ether reductase activity
D-xylose:NADP reductase activity
L-arabinose:NADP reductase activity
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
steroid dehydrogenase activity, acting on the CH-CH group of donors
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity
3-hydroxymenthone dehydrogenase activity
very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
dihydrotestosterone 17-beta-dehydrogenase activity
(R)-2-hydroxyisocaproate dehydrogenase activity
L-arabinose 1-dehydrogenase (NADP+) activity
L-xylulose reductase (NAD+) activity
3-ketoglucose-reductase activity
(R)-2-hydroxyglutarate dehydrogenase activity
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity
dehydrogenase
