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Invitrogen
REG3B Polyclonal Antibody
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FIGURE: 1 / 1
REG3B Antibody (PA5149959) in IHC (P)
Immunohistochemistry analysis of REG3B in paraffin-embedded Rat Rectum tissue. Samples were incubated with REG3B Polyclonal (Product # PA5149959) antibody using a dilution of 30 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5149959
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Regenerating Islet Derived Protein 3 Beta (REG3b) (Glu27-Gly175)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The REG3B gene encodes a protein that is part of the regenerating islet-derived (Reg) family, with significant roles in antimicrobial activity and tissue repair. REG3B is primarily expressed in the pancreas and is implicated in pancreatic regeneration, playing a critical role in conditions such as diabetes and pancreatitis. It exhibits potential therapeutic benefits in tissue injury and inflammatory disorders, including inflammatory bowel disease and acute liver injury. REG3B promotes acinar-to-ductal metaplasia through the activation of the RAS-RAF-MEK-ERK signaling pathway, suggesting its involvement in the early stages of pancreatic ductal adenocarcinoma development. Additionally, REG3B has been identified as an essential regulator of macrophage trafficking in cardiac healing post-myocardial ischemia, aiding in the recruitment and expansion of myeloid cells. Research aims to target REG3B and its receptors to interrupt pathological processes, offering promising avenues for treatment of pancreatic and extrapancreatic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Pancreatitis-associated protein 1; Peptide 23; Reg III-beta; REG-2; REG-3-beta; regenerating islet-derived protein 3 beta; Regenerating islet-derived protein 3-beta; Regenerating islet-derived protein III-beta; RegIII (beta)
Gene Aliases: HIP; Pap; PAP1; REG-III; Reg2; Reg3b
UniProt ID: (Rat) P25031, (Mouse) P35230
Entrez Gene ID: (Rat) 24618, (Mouse) 18489
acute-phase response
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
positive regulation of protein phosphorylation
inflammatory response
positive regulation of cell proliferation
negative regulation of neuron apoptotic process
negative regulation of cell death
negative regulation of hydrogen peroxide-induced neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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