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Invitrogen
RILPL1 Polyclonal Antibody
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产品信息
PA5-59512
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: LELDRLRLER MDRIEKERKH QKELELVEDV WRGEAQDLLS QIAQLQEENK QLMTNLSHKD VNFSEEEFQK HEGMSERERQ VMKKLKEV
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
靶标信息
Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution (PubMed:14668488). Binds to RAB10 following LRRK2-mediated RAB10 phosphorylation which leads to inhibition of ciliogenesis (PubMed:30398148). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: GAPDH competitor of SIAH protein enhances life; Rab interacting lysosomal protein-like 1; Rab-interacting lysosomal-like protein 1; RILP-like protein 1
基因别名: GOSPEL; RILPL1; RLP1
UniProt ID: (Human) Q5EBL4
Entrez Gene ID: (Human) 353116
