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Invitrogen
RKHD1 Polyclonal Antibody
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RKHD1 Antibody (PA5-95905) in WB
Western blot analysis of RKHD1 in mouse kidney. Samples were incubated with RKHD1 Polyclonal antibody (Product # PA5-95905) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
产品信息
PA5-95905
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human MEX3D (NP_9760493)
偶联物
形式
Liquid
浓度
0.54 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: AGARRSSGAG TPRHSPTLPE PGGLRLELPL SRRGAPDPVG ALSWRPPQGP VSFPGGAAFS TATSLPSSPA AAACAPLDSG ASENSRKPPS ASSAPALARE C
靶标信息
Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ring finger (C3HC4 type) and KH domain containing 1; RING finger and KH domain-containing protein 1; RNA-binding protein MEX3D
基因别名: BC059858; Mex3d; Rkhd1
UniProt ID: (Mouse) Q3UE17
Entrez Gene ID: (Mouse) 237400
