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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: ELEAECPVCW NPFNNTFHTP KMLDCCHSFC VECLAHLSLV TPARRRLLCP LCRQPTVLAS GQPVTDLPTD
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 94%.
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。