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Invitrogen
RNF220 Polyclonal Antibody
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RNF220 Antibody (PA5-110308) in WB
Western blot analysis of RNF220 in various lysates. Samples were incubated with RNF220 Polyclonal antibody (Product # PA5-110308) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-110308
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 267-566 of human RNF220 (NP_060620.2).
偶联物
形式
Liquid
浓度
1.86 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: PKSLLLSASI KREGESPTAS PHSSATDDLH HSDRYQTFLR VRANRQTRLN ARIGKMKRRK QDEGQREGSC MAEDDAVDIE HENNNRFEEY EWCGQKRIRA TTLLEGGFRG SGFIMCSGKE NPDSDADLDV DGDDTLEYGK PQYTEADVIP CTGEEPGEAK EREALRGAVL NGGPPSTRIT PEFSKWASDE MPSTSNGESS KQEAMQKTCK NSDIEKITED SAVTTFEALK ARVRELERQL SRGDRYKCLI CMDSYSMPLT SIQCWHVHCE ECWLRTLGAK KLCPQCNTIT APGDLRRIYL
靶标信息
E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: E3 ubiquitin-protein ligase RNF220; RING finger protein 220; RING-type E3 ubiquitin transferase RNF220
基因别名: 4732477A13; 4931406I20Rik; 5730503K05Rik; AV302541; C1orf164; RNF220
UniProt ID: (Human) Q5VTB9, (Mouse) Q6PDX6
Entrez Gene ID: (Human) 55182, (Rat) 500532, (Mouse) 66743
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
metal ion binding
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
