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Invitrogen

ROCK1/ROCK2 Recombinant Rabbit Monoclonal Antibody (HL1632)

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产品信息

MA5-50324

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:10,000
-

免疫组化（石蜡） (IHC (P))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

HL1632

抗原

Recombinant fragment of human ROCK1 .

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

规格

100 µg

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_3093954

靶标信息

ROCK1 and ROCK2 are genes that encode for Rho-associated coiled-coil containing protein kinases, also known as ROCKs. These kinases are involved in a variety of cellular processes such as cell migration, adhesion, proliferation, and apoptosis. They are activated by the small GTPase RhoA and phosphorylate downstream targets such as myosin light chain, LIM kinase, and myosin phosphatase. Dysregulation of ROCK1 and ROCK2 has been linked to various diseases including cancer, cardiovascular disease, and neurological disorders.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: liver regeneration-related protein LRRG199; p150 RhoA-binding kinase ROK beta; p150 ROK-alpha; p160 ROCK-1; p160ROCK; p164 ROCK-2; Renal carcinoma antigen NY-REN-35; Rho kinase 2; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 1; Rho-associated coiled-coil forming kinase 2; Rho-associated kinase beta; Rho-associated protein kinase 1; Rho-associated protein kinase 2; Rho-associated, coiled-coil-containing protein kinase 1; Rho-associated, coiled-coil-containing protein kinase 2; Rho-associated, coiled-coil-containing protein kinase I; Rho-associated, coiled-coil-containing protein kinase II; RhoA - binding serine/threosine kinase alpha (ROK - alpha); RhoA-binding kinase 2; ROCK-1/ROCK-2; ROCK-I; ROCK-I/ROCK-II; ROCK-II; ROKalpha; unnamed protein product

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基因别名: 1110055K06Rik; B230113H15Rik; KIAA0619; mKIAA0619; P160ROCK; Rho-kinase; ROCK-I; ROCK-II; ROCK1; ROCK2; Rock2m; ROK; ROKalpha

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UniProt ID: (Human) Q13464, (Human) O75116, (Mouse) P70335, (Rat) Q62868, (Mouse) P70336

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Entrez Gene ID: (Human) 6093, (Human) 9475, (Mouse) 19877, (Rat) 81762, (Rat) 25537, (Mouse) 19878

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功能
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding zinc ion binding kinase activity transferase activity small GTPase binding metal ion binding tau protein binding tau-protein kinase activity Rho-dependent protein serine/threonine kinase activity protein serine kinase activity protease binding RNA binding structural molecule activity endopeptidase activator activity transferase activity, transferring phosphorus-containing groups Rho GTPase binding GTP-Rho binding poly(A) RNA binding non-receptor serine/threonine protein kinase
参与通路
mitotic cytokinesis epithelial to mesenchymal transition aortic valve morphogenesis apical constriction apoptotic process smooth muscle contraction leukocyte cell-cell adhesion signal transduction Rho protein signal transduction regulation of gene expression positive regulation of autophagy positive regulation of macromolecule metabolic process positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of angiogenesis peptidyl-serine phosphorylation membrane to membrane docking actin cytoskeleton organization regulation of cell adhesion regulation of cell migration cortical actin cytoskeleton organization actomyosin structure organization neuron projection development bleb assembly negative regulation of protein binding regulation of actin cytoskeleton organization regulation of actin filament-based process intracellular signal transduction positive regulation of MAPK cascade regulation of keratinocyte differentiation regulation of neuron differentiation positive regulation of phosphate metabolic process embryonic morphogenesis leukocyte migration leukocyte tethering or rolling negative regulation of membrane protein ectodomain proteolysis myoblast migration regulation of stress fiber assembly regulation of focal adhesion assembly positive regulation of focal adhesion assembly mRNA destabilization negative regulation of biomineral tissue development regulation of microtubule cytoskeleton organization response to transforming growth factor beta protein localization to plasma membrane regulation of synapse maturation glomerular visceral epithelial cell migration motor neuron apoptotic process regulation of blood vessel diameter regulation of angiotensin-activated signaling pathway neuron projection arborization positive regulation of beta-amyloid clearance regulation of synaptic vesicle endocytosis regulation of cell junction assembly regulation of beta-amyloid formation negative regulation of beta-amyloid formation negative regulation of amyloid precursor protein catabolic process regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly positive regulation of connective tissue replacement response to angiotensin regulation of establishment of cell polarity regulation of cell motility negative regulation of motor neuron apoptotic process response to ischemia protein phosphorylation negative regulation of gene expression positive regulation of centrosome duplication positive regulation of cell migration regulation of neurological system process positive regulation of connective tissue growth factor production regulation of circadian rhythm stress fiber assembly modulation by host of viral process negative regulation of nitric oxide biosynthetic process rhythmic process centrosome duplication positive regulation of stress fiber assembly positive regulation of fibroblast growth factor production negative regulation of protein localization to lysosome regulation of cellular response to hypoxia positive regulation of beta-amyloid formation positive regulation of protein localization to early endosome positive regulation of amyloid precursor protein catabolic process cellular response to acetylcholine cytoskeleton organization phosphorylation negative regulation of neuron apoptotic process regulation of cytoskeleton organization neural tube closure extrinsic apoptotic signaling pathway via death domain receptors chromosome condensation dendrite morphogenesis
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