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Invitrogen
RON Polyclonal Antibody
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FIGURE: 1 / 4
RON Antibody (PA5-71878) in IHC (P)
Immunohistochemistry analysis of RON in formalin fixed and paraffin embedded mouse liver tissue. Samples were incubated with RON polyclonal antibody (Product # PA5-71878) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-71878
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
C. elegans,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1013-1041 amino acids from the C-terminal region of mouse Mst1r
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
MST1R (RON) is a receptor tyrosine kinase involved in cell proliferation and motility. The protein is a membrane-spanning, disulfide-linked heterodimer, which results from cleavage of a glycosylated precursor into 35-kD (alpha) and 150-kD (beta) subunits. Ligand binding results in tyrosine phosphorylation of the beta chain. In knockout studies, MST1R/RON (-/-) mice failed to survive past the periimplantation period. The MST1R/RON gene has been mapped to 3p21, a region of frequent deletion or mutation in small cell lung and renal carcinoma, and has been implicated in the progression of several epithelial cancers. MST1R/Ron expression has been documented in many normal human tissues. ESTs have been isolated from several tissue libraries, including normal colon, mouth, prostate, and testis and cancerous colon, prostate, stomach, and uteru.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD136; friend virus susceptibility 2; Macrophage-stimulating protein receptor; MSP receptor; MST1R variant RON30; MST1R variant RON62; p185-Ron; receptor protein tyrosine kinase, c-met-related; RON variant E2E3; Stem cell-derived tyrosine kinase
Gene Aliases: CD136; CDw136; Fv-2; Fv2; Mst1r; PTK8; Ron; STK
UniProt ID: (Mouse) Q62190
Entrez Gene ID: (Mouse) 19882
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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