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Invitrogen
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Immunogen sequence: RAAKVLEQLT GQTPVFSKAR YTVRSFGIRR NEKIAVHCTV RGAKAEEILE KGLKVREYEL RKNNFSDTGN FGFGIQEHID LGIKYDPSIG IYGLDFYVVL GRPGFSIADK KRRTGCIGAK HRISKEE
Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。