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Proteintech
RTN1 (Isoform RTN1-C) Polyclonal Antibody
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RTN1 (Isoform RTN1-C) Antibody (15048-1-AP) in IHC (P)
Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using (Product # 15048-1-AP) (RTN1 (Isoform RTN1-C) antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).
产品信息
15048-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RTN1 (Isoform RTN1-C) Fusion Protein Ag7031 (1-208 aa encoded by BC000314)
偶联物
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is raised against the full-length protein of human RTN1-C.
Immunogen sequence: MQATADSTK MDCVWSNWKS QAIDLLYWRD IKQTGIVFGS FLLLLFSLTQ FSVVSVVAYL ALAALSATIS FRIYKSVLQA VQKTDEGHPF KAYLELEITL SQEQIQKYTD CLQFYVNSTL KELRRLFLVQ DLVDSLKFAV LMWLLTYVGA LFNGLTLLLM AVVSMFTLPV VYVKHQAQID QYLGLVRTHI NAVVAKIQAK IPGAKRHAE (1-208 aa encoded by BC000314 )
靶标信息
Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i. e. reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight of ~135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Neuroendocrine-specific protein; Reticulon-1; S-rex
基因别名: NSP; RTN1
UniProt ID: (Human) Q16799, (Rat) Q64548, (Mouse) Q8K0T0
Entrez Gene ID: (Human) 6252, (Rat) 116644, (Mouse) 104001
