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Proteintech

RTN4/NOGO Polyclonal Antibody

15 篇参考文献
查看其他4个Nogo抗体

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说明书
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实验方案
问题与答案
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说明书
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实验方案
问题与答案
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说明书
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实验方案
问题与答案
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产品信息

10740-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200-1:1,000
查看13篇已发表文章 13篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
-

免疫细胞化学 (ICC/IF)

-
查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

0.2 µg/1x10^6 cells
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

RTN4/NOGO Fusion Protein Ag1164 (1-199 aa encoded by BC007109)

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.13 mg/mL

规格

19.5 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MDGQKKNWK DKVVDLLYWR DIKKTGVVFG ASLFLLLSLT VFSIVSVTAY IALALLSVTI SFRIYKGVIQ AIQKSDEGHP FRAYLESEVA ISEELVQKYS NSALGHVNCT IKELRRLFLV DDLVDSLKFA VLMWVFTYVG ALFNGLTLLI LALISLFSVP VIYERHQAQI DHYLGLANKN VKDAMAKIQA KIPGLKRKAE (1-199 aa encoded by BC007109)

靶标信息

Nogo, also known as RTN4, encodes a membrane protein that limits axon growth and regeneration in the central nervous system. The gene produces multiple isoforms (Nogo-A, Nogo-B, Nogo-C) via alternative promoters and splicing; Nogo-A is highly expressed in oligodendrocytes and is the principal inhibitor of neurite outgrowth. Nogo engages receptors including NgR1 (RTN4R), LINGO1, and p75 or TROY, activating RhoA/ROCK signaling that stabilizes growth cone collapse and restricts plasticity after injury. Beyond axon guidance, Nogo isoforms contribute to membrane dynamics, endoplasmic reticulum structure, vascular function, and immune signaling. Experimental blockade of Nogo or its receptor complex can enhance sprouting and functional recovery in animal models, making the pathway a target for therapies in spinal cord injury and stroke.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ASY; foocen; glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; My043 protein; neurite growth inhibitor 220; neurite outgrowth inhibition; RTN4; foocen; neurite outgrowth inhibitor; neuroendocrine-specific protein C homolog; NI-220/250; NOGO-A; RTN4-A; NOGO-B; RTN4-B1; NOGO-C; RNT4-C; NOGO-C; RTN4-C; reticulon; Reticulon 4; reticulon 5; Rtn4; RTN4-Aa; RTN4-Ab; RTN4-B2; RTN4-D; RTN4-E; RTN4-F; RTN4-G; RTN4; foocen; RTN4a; RTN4b; RTN4c; unnamed protein product; vp20

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基因别名: 1110020G17Rik; ASY; C130026I10Rik; mKIAA0886; mKIAA4153; Nbla00271; Nbla10545; NgA; NI-250; NI220/250; NOGO; Nogo-A; Nogo-B; Nogo-C; NOGOA; NOGOB; NSP; NSP-CL; rat N; rat NogoA; RTN-X; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; Vp20

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UniProt ID: (Human) Q9NQC3, (Mouse) Q99P72, (Rat) Q9JK11

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Entrez Gene ID: (Human) 57142, (Mouse) 68585, (Rat) 83765

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功能
RNA binding protein binding ubiquitin protein ligase binding protein homodimerization activity cadherin binding metal ion binding lipid binding macromolecular complex binding
参与通路
blastocyst formation leukocyte migration involved in inflammatory response endoplasmic reticulum organization nervous system development axonal fasciculation brain development positive regulation of epithelial cell migration negative regulation of neuron projection development cerebral cortex radial glia guided migration central nervous system vasculogenesis neuron differentiation negative regulation of cell growth regulation of cell migration negative regulation of axon extension positive regulation of mammary gland epithelial cell proliferation positive regulation of dopamine secretion positive regulation of toll-like receptor 9 signaling pathway positive regulation of Rac protein signal transduction cell migration involved in vasculogenesis negative regulation of neuron differentiation positive regulation of glial cell differentiation positive regulation of angiogenesis positive regulation of collateral sprouting of injured axon negative regulation of axonogenesis modulation of synaptic transmission protein stabilization nuclear pore complex assembly positive regulation of protein kinase B signaling regulation of nervous system development cardiac epithelial to mesenchymal transition positive regulation of macrophage cytokine production protein localization to lysosome negative regulation of neuron projection regeneration cellular response to hypoxia endoplasmic reticulum tubular network organization endoplasmic reticulum tubular network assembly cellular sphingolipid homeostasis cell adhesion involved in sprouting angiogenesis regulation of postsynapse assembly negative regulation of beta-amyloid formation positive regulation of neutrophil migration negative regulation of dendrite extension positive regulation of macrophage migration positive regulation of protein localization to endoplasmic reticulum positive regulation of ERBB3 signaling pathway positive regulation of artery morphogenesis negative regulation of formation of growth cone in injured axon endoplasmic reticulum tubular network membrane organization regulation of branching morphogenesis of a nerve positive regulation of hepatocyte proliferation negative regulation of vasculogenesis response to activity olfactory nerve development oligodendrocyte differentiation apoptotic process regulation of apoptotic process
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