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Proteintech
RUNX1T1 Polyclonal Antibody
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产品信息
15494-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Sheep
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RUNX1T1 Fusion Protein Ag7892 (1-351 aa encoded by BC005850)
偶联物
形式
Liquid
浓度
0.26 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MPDSPVDVK TQSRLTPPTM PPPPTTQGAP RTSSFTPTTL TNGTSHSPTA LNGAPSPPNG FSNGPSSSSS SSLANQQLPP ACGARQLSKL KRFLTTLQQF GNDISPEIGE RVRTLVLGLV NSTLTIEEFH SKLQEATNFP LRPFVIPFLK ANLPLLQREL LHCARLAKQN PAQYLAQHEQ LLLDASTTSP VDSSELLLDV NENGKRRTPD RTKENGFDRE PLHSEHPSKR PCTISPGQRY SPNNGLSYQP NGLPHPTPPP PQHYRLDDMA IAHHYRDSYR HPSHRDLRDR NRPMGLHGTR QEEMIDHRLT DREWAEEWKH LDHLLNCIMD MVEKTRRSLT VLRRCQEADR EE (1-351 aa encoded by BC005850)
靶标信息
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: acute myelogenous leukemia 1 translocation 1 protein; acute myelogenous leukemia 1 translocation 1, cyclin-D related; CBFA2T1 identified gene homolog; CBFA2T1 isoform r1t1-11a61; CBFA2T1 isoform r1t1-11a62; CBFA2T1 isoform r1t1-11a63; CBFA2T1 isoform r1t1-11a64; CBFA2T1 isoform r1t1-11a65; CBFA2T1 isoform r1t1-7a47; CBFA2T1 isoform r1t1-7a48; CBFA2T1 isoform r1t1-7a49; CBFA2T1 isoform r1t1-7a50; CBFA2T1 isoform r1t1-7a51; CBFA2T1 isoform r1t1-7a52; CBFA2T1 isoform r1t1-7d53; CBFA2T1 isoform r1t1-7d54; CBFA2T1 isoform r1t1-7d55; CBFA2T1 isoform r1t1-7d56; CBFA2T1 isoform r1t1-8a57; CBFA2T1 isoform r1t1-8a58; CBFA2T1 isoform r1t1-8a59; CBFA2T1 isoform r1t1-8a60; core-binding factor, runt domain, alpha subunit 2, translocated to, 1; core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related; cyclin D-related; Cyclin-D-related protein; Eight twenty one protein; MGC2796; MTG8b; myeloid translocation gene on 8q22; Protein CBFA2T1; Protein ETO; Protein MTG8; runt related transcription factor 1; translocated to, 1 (cyclin D related); runt-related transcription factor 1; translocated to, 1 (cyclin D-related); translocated to, 1; Zinc finger MYND domain-containing protein 2
基因别名: AML1-MTG8; AML1T1; CBFA2T1; Cbfa2t1h; CDR; ETO; MTG8; RUNX1T1; ZMYND2
UniProt ID: (Human) Q06455, (Mouse) Q61909
Entrez Gene ID: (Human) 862, (Rat) 362489, (Mouse) 12395
