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Proteintech
RabGEF1 Polyclonal Antibody
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产品信息
12735-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
RabGEF1 Fusion Protein Ag3442 (136-491 aa encoded by BC015330)
偶联物
形式
Liquid
浓度
0.13 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: DRVSKEFIE FLKTFHKTGQ EIYKQTKLFL EGMHYKRDLS IEEQSECAQD FYHNVAERMQ TRGKVPPERV EKIMDQIEKY IMTRLYKYVF CPETTDDEKK DLAIQKRIRA LRWVTPQMLC VPVNEDIPEV SDMVVKAITD IIEMDSKRVP RDKLACITKC SKHIFNAIKI TKNEPASADD FLPTLIYIVL KGNPPRLQSN IQYITRFCNP SRLMTGEDGY YFTNLCCAVA FIEKLDAQSL NLSQEDFDRY MSGQTSPRKQ EAESWSPDAC LGVKQMYKNL DLLSQLNERQ ERIMNEAKKL EKDLIDWTDG IAREVQDIVE KYPLEIKPPN QPLAAIDSEN VENDKLPPPL QPQVYAG (136-491 aa encoded by BC015330 )
靶标信息
RABGEF1 forms a complex with rabaptin-5 (RABPT5) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: RAB guanine nucleotide exchange factor (GEF) 1; Rab5 exchange factor; Rab5 GDP/GTP exchange factor; Rabaptin-5-associated exchange factor for Rab5; Rabex-5; RAP1; Ras negative regulator Rabex-5; Ras negative regulator Rabex-5/Rin2
基因别名: Rab5ef; rabex-5; RABEX5; RABGEF1; RAP1; Rin2
UniProt ID: (Human) Q9UJ41, (Mouse) Q9JM13
Entrez Gene ID: (Human) 27342, (Mouse) 56715, (Rat) 360797
negative regulation of protein phosphorylation
negative regulation of leukocyte migration
protein targeting to membrane
endocytosis
protein ubiquitination
negative regulation of mast cell degranulation
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
negative regulation of receptor-mediated endocytosis
negative regulation of inflammatory response
regulation of Fc receptor mediated stimulatory signaling pathway
negative regulation of interleukin-6 secretion
negative regulation of Kit signaling pathway
transport
protein transport
negative regulation of mast cell activation
