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Invitrogen
Rb Polyclonal Antibody
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产品信息
PA1-14370
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to human Rb.
偶联物
Unconjugated
Unconjugated
Unconjugated
保存条件
-20°C, Avoid Freeze/Thaw Cycles
产品详细信息
PA1-14370 detects Rb in human, mouse and rat samples.
PA1-14370 has been successfully used in Western blot and immunohisotchemistry procedures.
The PA1-14370 immunogen is a synthetic peptide derived from human Rb around the phosphorylation site of serine 807 (Y-I-S-P-P-L).
靶标信息
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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