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Invitrogen
Rb Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-120020
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human RB (NP_000312.2).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.42 mg/mL
规格
42 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive test controls include: HeLa, A-431. The target is usually found in the following locations: Nucleus.
Immunogen sequence: RSTSQNLDSG TDLSFPWILN VLNLKAFDFY KVIESFIKAE GNLTREMIKH LERCEHRIME SLAWLSDSPL FDLIKQSKDR EGPTDHLESA CPLNLPLQNN H
靶标信息
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cleaved Rb; delta RB-p70; DRb-p70; p105-Rb; P105RB; p110-RB1; Phospho-Retinoblastoma; pp110; pRb; Rb; Rb-p70; Retin; Retinoblastoma; retinoblastoma gene; Retinoblastoma-associated protein
基因别名: RB1
Entrez Gene ID: (Human) 5925
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