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Invitrogen
Reg3D Monoclonal Antibody (518818)
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Reg3D Antibody (MA5-24226) in IHC (P)
Immunohistochemical analysis of Reg3D in immersion fixed paraffin-embedded sections of mouse pancreas. Samples were incubated with Reg3D Monoclonal Antibody (Product # MA5-24226) using a dilution of 15 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Rat IgG HRP Secondary Antibody. Tissue was stained with DAB (brown) and counterstained with hematoxylin (blue).
产品信息
MA5-24226
产品规格
种属反应
Mouse
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
518818
抗原
E. coli-derived recombinant mouse Reg3D Glu27-Gly175
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant human (rh) Reg1A, 1B, recombinant mouse (rm) Reg1, 2, 3A, 3B, 3G, 4, or recombinant rat Reg3 is observed.
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
The Reg3D gene encodes the regenerating islet-derived protein 3 delta, a member of the Reg protein family, which is involved in tissue regeneration, particularly within the pancreas. Reg3D proteins are known for their significant roles in the protection and regeneration of pancreatic islet cells, aiding in the maintenance of glucose homeostasis during pancreatic stress or damage. They possess bactericidal properties, contributing to the innate immunity of the gastrointestinal tract by providing a defensive mechanism against microbial invasion. The expression of Reg3D is upregulated in response to intestinal bacterial infections, supporting mucosal defenses and preventing pathogen colonization. While closely related to other Reg family members, Reg3D's specific functions and regulatory mechanisms continue to be elucidated, with ongoing research exploring its potential therapeutic applications in conditions such as diabetes and pancreatitis. Understanding the role of Reg3D in pancreatic and gastrointestinal health is crucial for developing strategies to enhance tissue repair and immune functions in related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: islet neogenesis associated protein-related protein; Reg III delta; regenerating islet-derived 3 delta
基因别名: INGAP; Ingaprp
Entrez Gene ID: (Mouse) 30053
