A synthetic peptide from the internal region of human Rho related GTP binding protein RhoU (CDC42 like GTPase 1, CDC42L1, Ryu GTPase) conjugated to an immunogenic carrier protein was used as the antigen

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

Conc. Not Determined

纯化类型

Ammonium sulfate precipitation

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

The antigen shares 90% identity with rat and mouse sequence.

Specificity of this antibody: RhoU.

靶标信息

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: 2310026M05Rik; CDC42-like GTPase 1; GTP-binding protein like 1; GTP-binding protein SB128; GTP-binding protein-like 1; ras homolog gene family, member U; ras-like gene family member U; Ras-like protein member U; Rho GTPase-like protein ARHU; Rho-related GTP-binding protein RhoU; RHOU; Ryu GTPase; similar to ras homolog gene family, member U; Wnt-1 responsive Cdc42 homolog 1; Wnt1 responsive Cdc42 homolog; WRCH-1

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基因别名: 2310026M05Rik; AI182090; ARHU; CDC42L1; G28K; hG28K; mG28K; RHOU; SB128; WRCH-1; WRCH1

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UniProt ID: (Human) Q7L0Q8, (Mouse) Q9EQT3

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Entrez Gene ID: (Rat) 678766, (Human) 58480, (Mouse) 69581

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功能

GTPase activity protein binding GTP binding metal ion binding nucleotide binding small GTPase

参与通路

G1/S transition of mitotic cell cycle cytoskeleton organization regulation of cell shape Rac protein signal transduction actin cytoskeleton organization regulation of small GTPase mediated signal transduction positive regulation of protein targeting to mitochondrion small GTPase mediated signal transduction